World Trade Center (WTC) first responders are at risk for developing dementia, according to two studies led by Stony Brook University researchers and presented virtually at the Alzheimer’s Association International Conference on July 28, 2020. The studies included individuals with signs of cognitive impairment (CI) who show neuroradiological abnormalities and changes in their blood similar to that seen in Alzheimer’s disease patients and those with related dementias. One study in Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring (DADM) shows that many responders with CI have reduced gray matter thickness in the brain consistent with neurodegenerative conditions and evidence their brain “age” is about 10 years older on average than the normal population. This research is in collaboration with scientists at the Icahn School of Medicine at Mount Sinai.