Fire officials re-opened False River Road around 6 p.m. after battling a multi-story house fire since earlier Sunday afternoon.
According to Point Coupee Fire District 5, the fire has been extinguished but the building is a total loss.
Chief Pedro Leonard says the cause of the fire is still under investigation, but no injuries have been reported at this time.
Several firefighters had to be treated for heat exposure, but all crews and personnel are back to normal, he added.
It took all five Point Coupee Parish fire districts as well as West Feliciana and Zachary to help put out this fire.