The Waynesboro Fire Department responded to the 800 block of Grayson Ave. around 4:30 Friday morning for reports of a house fire.
When the fire department arrived, the incident commander found thick smoke conditions coming from the single-family home.
All occupants were able to evacuate; however, some sustained various levels of burn injuries, and all occupants sustained some degree of smoke inhalation injuries.
A family friend said an elderly resident is suffering very bad burns, but other family members are recovering.
Two pets were unable to make it out of the home and died as a result of the fire.
The Waynesboro Fire Department was assisted by fire crews from Dooms Volunteer Fire Department and Augusta County Fire and Rescue to extinguish the fire.