The Delaware Division of Public Health reported the state’s fourth, fifth and sixth suspected cases of monkeypox (MPX). All cases are considered probable pending confirmatory testing by the Centers for Disease Control and Prevention. The three most recent cases involve a 42-year-old Kent County man and two New Castle County men, one a 19-year-old and one a 24-year-old. The cases were unrelated and none of the individuals reported recent travel. While at least one individual confirmed close intimate contact with another individual, none reported close contact with someone known to have monkeypox. All three individuals reported close contact with a limited number of individuals and are self-isolating.